ea0065oc1.5 | Metabolism and Obesity | SFEBES2019
Cuozzo Federica
, Nasteska Daniela
, Thakker Alpesh
, Westbrook Rebecca
, Bakar Rula Bany
, Cantley James
, Tennant Daniel
, Hodson David J
Aims: Prolyl-4 hydroxylase domain protein 3 (PHD3) is an alpha ketoglutarate-dependent dioxygenase involved in the oxygen-dependent regulation of cell phenotype. While PHD3 has been reported to suppress insulin sensitivity in the liver, little is known about effects of the enzyme in insulin-secreting β-cells.Methods: βPHD3−/− mice were generated by crossing the Ins1Cre driver line with animals bearing a floxed Egln3</...